Chromosomal Imbalances in the Colorectal Carcinomas with Microsatellite Instability
β Scribed by Long Shan Li; Nam-Gyun Kim; Se Hoon Kim; Chanil Park; Hyunki Kim; Hyun Ju Kang; Kwi Hye Koh; Soo Nyung Kim; Won Ho Kim; Nam Kyu Kim; Hoguen Kim
- Book ID
- 117021686
- Publisher
- American Society for Investigative Pathology
- Year
- 2003
- Tongue
- English
- Weight
- 498 KB
- Volume
- 163
- Category
- Article
- ISSN
- 0002-9440
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## Abstract Genetic changes related to colorectal carcinomas are accumulated in individual tumor glands during disease progression. Microsatellite allelic analysis of individual tumor glands from 30 colorectal carcinomas using a polymerase chain reaction (PCR) assay coupled with crypt isolation was
Very recently a new molecular mechanism in the tumorigenesis of colorectal carcinoma has been described which is closely linked to hereditary non-polyposis colonic cancer (HNPCC). Ubiquitous changes in the length of simple repetitive DNA sequences between constitutional and tumour DNA occur in about