Chromosomal imbalances in human lung cancer
β Scribed by Balsara, Binaifer R; Testa, Joseph R
- Book ID
- 110066991
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 137 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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The relatively frequent loss of heterozygosity at loci on the short arm of chromosome I I in human lung cancers has suggested the presence of a putative tumor suppressor gene. For location of the gene, a fine deletion map of human chromosome I I was constructed by analysis of DNAs from 79 lung cance
We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (Al, allelic loss or allelic gain) in the tumor. Here we report the statist
## Abstract We have determined regions of allelic imbalance in human breast cancer cells using highly polymorphic microsatellite markers, which can be rapidly typed by the polymerase chain reaction (PCR) using very small amounts of DNA. It appears that there are several regions of chromosome I whic