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Chromosomal changes: Radiation sensitive sites on chromosome 2 and their role in radiation myeloid leukaemogenesis in the mouse

โœ Scribed by R. Cox; G. Breckon; A. R. J. Silver; W. K. Mason; A. M. George

Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
219 KB
Volume
30
Category
Article
ISSN
0301-634X

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Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (/L)-/a and p map to this region, and the p gene is deregulated in some AMLs. Using pulsed-field gel electrophoresis techniques,