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Chromosomal analysis in non-myxoid and dedifferentiated myxoid liposarcomas

✍ Scribed by B.E.Ch. Plaat; P. Sars; M.F. Mastik; W.M. Molenaar; H.J. Hoekstra; E. van den Berg


Book ID
114136530
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
104 KB
Volume
91
Category
Article
ISSN
0165-4608

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Myxoid liposarcomas (MLS) carry a t(12;16) or, more rarely, a t(12;22) resulting in fusion of the transcription factor gene CHOP on chromosome 12 with TLS/FUS on chromosome 16 or EWS on chromosome 22. The chimeric TLS-CHOP or EWS-CHOP proteins most probably function as abnormal transcription factors