𝔖 Bobbio Scriptorium
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Chromosomal abnormalities in human breast cancer

✍ Scribed by Wendy M. Mars; Grady F. Saunders

Book ID
104622919
Publisher
Springer
Year
1990
Tongue
English
Weight
733 KB
Volume
9
Category
Article
ISSN
0167-7659

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✦ Synopsis

This review emphasizes cytogenetic changes and DNA analyses by Southern blot in primary breast tumors, rather than metastases, established cell lines, and pleural effusions. The data suggests that the most frequently altered chromosomes and chromosome regions are lp, lq, 2q, 3p, 6q, 8p, 8q, llp, llq, 13q, 14q, 17p, and 17q. Changes on 8q, llp, llq, 13q, and 17q appear to be associated with either progression of the disease or poor prognosis. Alterations on lp and 3p may represent early events in the development of breast cancer.

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