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Chromosomal instability in breast cancer patients

✍ Scribed by Leonardo Barrios; M. R. Caballín; Rosa Miró; Carme Fuster; Ferràn Guedea; Antoni Subias; Josep Egozcue

Publisher
Springer
Year
1991
Tongue
English
Weight
457 KB
Volume
88
Category
Article
ISSN
0340-6717

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✦ Synopsis

We have carried out cytogenetic studies, using the G-banding technique, in peripheral blood lymphocytes of 10 patients affected by breast carcinoma. The frequency of aberrant metaphases (7.36%) is significantly different from that of our laboratory controls (3.76% of aberrant metaphases) but not from that detected in patients suffering from bladder cancer (10.64%) and Hodgkin's disease (11.03%), two conditions that have previously been described as chromosomally unstable. Our results suggest that breast carcinoma patients show a degree of chromosomal instability that could be related to a predisposition to neoplastic disease.

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