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Chromosomal aberrations in a case of T-cell CLL with concomitant IgA myeloma

✍ Scribed by L. Zech; L. Hammarström; C. I. E. Smith


Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
430 KB
Volume
32
Category
Article
ISSN
0020-7136

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✦ Synopsis


Abstract

Four consistent markers, involving chromosomes 8, 11, 14, 18, 21 and 22, were found in the majority of meta‐phases obtained after stimulation of peripheral blood and bone marrow from a patient with a T‐cell chronic lym‐phocytic leukemia (CLL) and a concomitant IgA/lambda myeloma with phytohemagglutinin (PHA), lipopolysac‐charide of E. coli(LPS) and S. aureus strain Cowan I bacteria (Cowan). A second malignant clone with three additional markers was observed after stimulation with Con‐canavalin A (Con A). A chromosome 14 aberration, inv(14) (q11‐q32), may be of significance in the T‐cell malignancy and may suggest a common clonal origin of the two tumors.


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