Chromosomal aberrations in a case of T-cell CLL with concomitant IgA myeloma
✍ Scribed by L. Zech; L. Hammarström; C. I. E. Smith
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 430 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Four consistent markers, involving chromosomes 8, 11, 14, 18, 21 and 22, were found in the majority of meta‐phases obtained after stimulation of peripheral blood and bone marrow from a patient with a T‐cell chronic lym‐phocytic leukemia (CLL) and a concomitant IgA/lambda myeloma with phytohemagglutinin (PHA), lipopolysac‐charide of E. coli(LPS) and S. aureus strain Cowan I bacteria (Cowan). A second malignant clone with three additional markers was observed after stimulation with Con‐canavalin A (Con A). A chromosome 14 aberration, inv(14) (q11‐q32), may be of significance in the T‐cell malignancy and may suggest a common clonal origin of the two tumors.
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