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Chromium reduces the in vitro activity and fidelity of DNA replication mediated by the human cell DNA synthesome

✍ Scribed by Heqiao Dai; Jianying Liu; Linda H. Malkas; Jennifer Catalano; Srilakshmi Alagharu; Robert J. Hickey

Book ID
113924478
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
956 KB
Volume
236
Category
Article
ISSN
0041-008X

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## Abstract We previously reported on the purification and characterization of a functional multi‐protein DNA replication complex (the DNA synthesome) from human cells and tissues. The synthesome is fully competent to carry‐out all phases of the DNA replication process in vitro. In this study, DNA