𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chromatographic Determination of Drugs and Their Metabolites for Phenotyping Cytochrome P-450 Isoenzymes

✍ Scribed by G. V. Ramenskaya


Book ID
106491341
Publisher
Springer
Year
2005
Tongue
English
Weight
98 KB
Volume
39
Category
Article
ISSN
0091-150X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Anthocyanins and their metabolites are w
✍ Andrea Dreiseitel; Peter Schreier; Anett Oehme; Sanja Locher; Goeran Hajak; Phil πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 338 KB

## Abstract The cytochrome P450 enzyme cytochrome P450 3A4 (CYP3A4) controls the metabolism of about 60% of all drugs, and its inhibition may dramatically affect drug safety. Modulation of cytochrome P450 activity has been observed by constituents of fruit extracts including several flavonoids. The

A Panel of Cytochrome P450 BM3 Variants
✍ Andrewβ€…M. Sawayama; Michaelβ€…M.β€…Y. Chen; Palaniappan Kulanthaivel; Ming-Shang Kuo πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 251 KB

## Abstract Herein we demonstrate that a small panel of variants of cytochrome P450 BM3 from __Bacillus megaterium__ covers the breadth of reactivity of human P450s by producing 12 of 13 mammalian metabolites for two marketed drugs, verapamil and astemizole, and one research compound. The most acti