Chromatin Remodeling by RNA Polymerase II
β Scribed by V. M. Studitsky
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2005
- Tongue
- English
- Weight
- 267 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0026-8933
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## Abstract We present a molecular model of eukaryotic gene transcription. For the Ξ²βglobin locus, we hypothesise that a transcription machine composed of multiple RNA polymerase II (PolII) assembles using the locus control region as a foundation. Transcription and locus remodelling can be achieved
The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA-directed processes in chromatin, it is often necessary