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Chromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling

✍ Scribed by Gang G. Wang; C. David Allis; Ping Chi

Book ID: 116758105
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 479 KB
Volume: 13
Category: Article
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2007.07.004

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The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA-directed processes in chromatin, it is often necessary