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Chromatin and cell surface receptors mediate melanoma cell growth response to nerve growth factor

✍ Scribed by Ewa M. Rakowicz-Szulczynska; Usha Reddy; Andrzej Vorbrodt; Dorothee Herlyn; Hilary Koprowski

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
873 KB
Volume
4
Category
Article
ISSN
0899-1987

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✦ Synopsis

Growth response to nerve growth factor (NGF) was tested in the primary melanoma cell line WM 164, which expressed a low level of NGF cell-surface receptor, and in WM 164 cells transfected with cDNA for the cell-surface receptor (TrWM 164 cells), which expressed a higher level of the cell-surface receptor. Neither cell line expressed the chromatin receptor for NGF or internalized NGF. Both cell lines were stimulated to growth by NGF. After 10 d of exposure to NGF, a 230,000 Mr chromatin protein (receptor) was induced in both cell lines; as a result, NGF bound to the chromatin, and ribosomal RNA synthesis and cell proliferation were inhibited. We suggest that the cell-surface and chromatin receptors each mediate a different function of NGF.

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