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Chondrochloren A and B, New β-Amino Styrenes from Chondromyces crocatus (Myxobacteria)

✍ Scribed by Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard Höfle

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
145 KB
Volume
2003
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

In a screening for biologically active metabolites of the genus Chondromyces, two novel metabolites, chondrochloren A (1) and B (2), were isolated from several strains of C. crocatus. Compounds 1 and 2 are unique chloro‐hydroxy‐styryl amides of a highly modified C~14~ carboxylic acid, which comprises an unsaturated ketone, two hydroxy, two methoxy and three methyl groups. After assignment of the absolute configuration of both carbinol stereocenters by Mosher’s method, NMR spectroscopic data combined with MM2 calculations allowed the prediction of the preferred conformation in solution. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

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✍ Jansen, Rolf ;Kunze, Brigitte ;Reichenbach, Hans ;Höfle, Gerhard 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

## Abstract As a result of the extension of our screening to strains of __Chondromyces__ four new antifungal and highly cytostatic depsipeptides were isolated, the chondramides A (1) – D (4). Their macrocyclic structures comprise three amino acids and a polyketide, viz. alanine, __N__‐methyltryptop