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Antibiotics from Gliding Bacteria, LXX Chondramides A-D, New Cytostatic and Antifungal Cyclodepsipeptides from Chondromyces crocatus (Myxobacteria): Isolation and Structure Elucidation

✍ Scribed by Jansen, Rolf ;Kunze, Brigitte ;Reichenbach, Hans ;Höfle, Gerhard

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
525 KB
Volume
1996
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

As a result of the extension of our screening to strains of Chondromyces four new antifungal and highly cytostatic depsipeptides were isolated, the chondramides A (1) – D (4). Their macrocyclic structures comprise three amino acids and a polyketide, viz. alanine, N‐methyltryptophan, α‐methoxyl‐β‐tyrosine, and a 7‐hydroxytrimethyloctenoic acid. Thus, they were found to be closely related to a small class of cyclodepsipeptides including jaspamide, the geodiamolides, and neosiphoniamolide which all have been isolated from marine sponges.

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