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Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

✍ Scribed by Laursen, Bettina; Mørk, Arne; Plath, Niels; Kristiansen, Uffe; Bastlund, Jesper Frank

Book ID
121940461
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
482 KB
Volume
240
Category
Article
ISSN
0166-4328

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## Abstract Age‐related metabolic changes in the hippocampus of APP~Swe~/PS1~dE9~ mice were measured with long echo‐time in vivo ^1^H‐magnetic resonance spectroscopy (^1^H‐MRS). Thioflavine S staining and Nissl staining were used to characterize deposition of Aβ aggregates and neuronal degeneration