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Cholesterol in Alzheimer's Disease and Tauopathy

✍ Scribed by MARK BURNS; KAREN DUFF

Book ID: 111397816
Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 227 KB
Volume: 977
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.2002.tb04839.x

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## Abstract Fundamental questions on the pathogenesis of Alzheimer's disease (AD) are how nontoxic, soluble amyloid β‐protein (Aβ) is converted to its toxic, aggregated form and how functional tau is hyperphosphorylated to form neurofibrillary tangles. Growing evidence from recent biochemical and c