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Cholesterol, hedgehog and embryogenesis

โœ Scribed by Herz, Joachim; Willnow, Thomas E.; Farese, Robert V.


Book ID
109915215
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
256 KB
Volume
15
Category
Article
ISSN
1061-4036

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## Abstract The close link between signaling by the developmental regulators of the Hedgehog family and cholesterol biochemistry has been known for some time. The morphogen is covalently attached to cholesterol in a peculiar autocatalytic reaction and embryonal disruption of cholesterol synthesis l