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Cholesterol changes in Alzheimer's disease: methods of analysis and impact on the formation of enlarged endosomes

✍ Scribed by Jack-Christophe Cossec; Catherine Marquer; Mai Panchal; Adina N. Lazar; Charles Duyckaerts; Marie-Claude Potier

Book ID
116273509
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
444 KB
Volume
1801
Category
Article
ISSN
1388-1981

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## Abstract The two‐point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age‐dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage.