Thirteen children, aged 10 months to 20 years, presenting with chronic cholestasis from the first month of life and with low serum levels of vitamins A and/or E, have been investigated for neurological and ophthalmological symptoms. Clinical findings consisted of 4 types: peripheral neuropathy; cere
Cholestasis and vitamin E deficiency: Neurologic disorders
β Scribed by Fernando Alvarez; Daniel Alagille
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 261 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0270-9139
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A 22-year-old man presented with progressive gait instability, tremor, and dysarthria since childhood. Electrophysiologic studies revealed a sensorimotor polyneuropathy. Laboratoty studies documented vitamin E deficiency; however, no gastrointestinal, hepatic, or lipoprotein disorder could be identi
Although secondary vitamin E deficiency causes a reversible neurologic disorder in children with chronic cholestasis, the effect of this deficiency state on other organ systems is unknown. We studied the effects of vitamin E therapy on selected gastrointestinal and hepatic functions in five children