✦ LIBER ✦

Cholera toxin and analogues of cyclic AMP stimulate the growth of cultured human mammary epithelial cells

✍ Scribed by Joyce Taylor-Papadimitriou; Patricia Purkis; Ian S. Fentiman

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 454 KB
Volume: 102
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041020306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The growth of human mammary epithelial cells is stimulated by cholera toxin and analogues of cyclic AMP, while the growth of breast derived fibroblasts is inhibited. These compounds have little effect on DNA synthesis in the absence of other mitogens but show a synergistic effect with serum and/or EGF. The results suggest that high intracellular levels of cyclic AMP in human mammary epithelial cells increase the growth response of the cell to mitogens.

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