Choice of thin-layer chromatographic systems for the routine screening for neutral drugs during toxicological analyses

✍ Scribed by P. Owen; A. Pendlebury; A.C. Moffat

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 417 KB
• Volume: 161
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)85226-2

✦ Synopsis

The efficiencies of fifteen thin-layer silica gel chromatographic systems for separating commonly encountered neutral drugs are compared. The discriminating powers of the systems are measured both individually and in combination. Chloroform-acetone (4:1) is found to be the best system. The combination of the ethyl acetate-methanol-ammonia (85:10:5) system with this gives the best pair of systems. A suitable sequence of spray reagents is also suggested. The chloroform-acetone (4:1) system is recommended as the best system to use when screening for both acidic and neutral drugs.