Choice of thin-layer chromatographic systems for the routine screening for acidic drugs during toxicological analyses

✍ Scribed by P. Owen; A. Pendlebury; A.C. Moffat

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 662 KB
• Volume: 161
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)85227-4

✦ Synopsis

The efficiencies of fifteen thin-layer silica gel chromatographic systems in separating commonly encountered acidic drugs are compared. The discriminating powers of the systems are measured both individually and in combination. Ethyl acetate and chloroform-methanol (9:l) are found to be-the two best systems. The combination of the ethyl acetate-methanol-ammonia (85:10:5) system with either of these gives the best pair of systems. Various sequences of spray reagents are also examined.