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Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans

✍ Scribed by Vladimir M Mishin; Alan S Rosman; Prithwijit Basu; Irina Kessova; Carl M Oneta; Charles S Lieber


Book ID
119395793
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
96 KB
Volume
93
Category
Article
ISSN
0002-9270

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Chlormethiazole inhibition of cytochrome
✍ A C Gebhardt; D Lucas; J Menez; H K Seitz πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 213 KB

Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in