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Chlorpromazine metabolism VII: New quantitative fluorometric determination of chlorpromazine and its sulfoxide

โœ Scribed by Pushkar N. Kaul; Lloyd R. Whitfield; Mervin L. Clark


Book ID
102914285
Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
691 KB
Volume
65
Category
Article
ISSN
0022-3549

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โœฆ Synopsis


Combining Eqs. A2 and A3 and intematinp: with these boundary For h d >> 1, h. A10 can be reduced to: -conditions give: C f -D " C m + (cf.+=)(l-;) Df Df for (0 5 x 5 h). dr2 D m ( D f : ) Substituting Eq. A4 into Eq. A3 and rearranging give: d*C,-k/ D,+-c,= Equation Ad can be solved analytically for C, to give: (%to + DmCmo) (1 -; ) Dm + Df/K where:

(Eq. A4)

(Eq. All)

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๐Ÿ“œ SIMILAR VOLUMES


Chlorpromazine metabolism VIII: Blood le
โœ Pushkar N. Kaul; Lloyd R. Whitfield; Mervin L. Clark ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 459 KB

A procedure was standardized for extracting chloropromazine and its sulfoxide from the blood and for applying a recently developed fluorometric assay method to determine blood levels of these two compounds in schizophrenic patients receiving chlorpromazine therapy. The described methodology opens av