Chlorambucil vs. combined chlorambucil-corticosteroid therapy in chronic lymphocytic leukemia
β Scribed by Tin Han; Ediz Z. Ezdinli; Katsutaro Shimaoka; Dinesh V. Desai
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 511 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0008-543X
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In a pilot study of the combination of epirubicin and chlorambucil in the treatment of chronic lymphocytic leukemia (CLL), 10 patients with advanced or progressive disease were treated in four centres. Up to a total of 15 courses in individual patients were given. Toxicity was relatively mild with n
Background. The clinical course of chronic lymphocytic leukemia (CLL) is variable. Staging systems define high risk groups, such as patients with Rai's Stage I11 and LV and Binet's stage C disease, as having a poor overall median survival. Most combination therapy programs have resulted in similar r
Ninety-six patients with advanced chronic lymphocytic leukemia (CLL) (Stage C; anemia and/or thrombocytopenia of nonimmune origin) were randomized to receive either chlorambucil (CLR) (0.4 mg/kg orally, day 6) plus prednime (PDN) (60 mg/m2 orally, days 1-5) every 2 weeks or cyclophosphamide (600 mg/