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Chk2 down-regulation by promoter hypermethylation in human bulk gliomas

โœ Scribed by Hongwei Wang; Shuai Wang; Liqin Shen; Yuanyuan Chen; Xiaotian Zhang; Jundong Zhou; Zhi Wang; Chengyi Hu; Wu Yue; Huibo Wang

Book ID
116719728
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
659 KB
Volume
86
Category
Article
ISSN
0024-3205

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## Abstract It has recently been demonstrated that CXCL12 is absent in colonic carcinoma, and hypermethylation of CXCL12 contributes to CXCL12/CXCR4 signaling in carcinoma metastasis. However, the role of CXCL12/CXCR4 axis, especially CXCL12, in the regulation of tumor invasiveness is largely still