Oxytocin, a nonapeptide amide, was synthesized on a PEGA-resin using the Fmoc-tBu strategy. The sulfhydryl groups of the two cysteine residues were protected with trityl groups. Different oxidation reagents such as DMSO, 12 and thallium(III) trifluoroacetate mixed with TFA were evaluated in order to
Chirooptical Properties of the Cystine Disulfide Bond
โ Scribed by Prof. Dr. R. Schwyzer
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 121 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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## Abstract Oligonucleotide duplexes with cystine disulfide 3โฒโ3โฒ interstrand crossโlinks were synthesized. Stepwise solidโphase procedures, followed by basic deprotection under controlled conditions and air oxidation, afforded various disulfideโlinked duplexes differing in the peptide and oligonuc
Tandem mass spectrometry employing high-energy, collisionally activated dissociation (CAD) is shown to be a useful method for sequencing through the cystine bridge of intermolecularly disulfide-bonded peptides. A characteristic triplet of intense fragment ions is observed corresponding to cleavage t