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Linking the 3′ Ends of Oligonucleotide Duplexes with Cystine Disulfide Bridges

✍ Scribed by Vicente Marchán; Daniel Pulido; Enrique Pedroso; Anna Grandas

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 193 KB
Volume: 2006
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200500567

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✦ Synopsis

Abstract

Oligonucleotide duplexes with cystine disulfide 3′‐3′ interstrand cross‐links were synthesized. Stepwise solid‐phase procedures, followed by basic deprotection under controlled conditions and air oxidation, afforded various disulfide‐linked duplexes differing in the peptide and oligonucleotide composition and length. Some of these nucleopeptides form unimolecular duplexes in which peptide–minor‐groove interactions are established, while others may give rise to extended nanostructures. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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