A poke in the eye: Inhibiting HIV-1 prot
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Kelly L. Damm; Peter M. U. Ung; Jerome J. Quintero; Jason E. Gestwicki; Heather
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Article
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2008
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Wiley (John Wiley & Sons)
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English
β 527 KB
## Abstract A novel mechanism of inhibiting HIVβ1 protease (HIVp) is presented. Using computational solvent mapping to identify complementary interactions and the Multiple Protein Structure method to incorporate protein flexibility, we generated a receptorβbased pharmacophore model of the flexible