Antilens antibodies in cataract and inflammatory eye disease: an evaluation of a new technique

✍ Scribed by M. Patel; B. Shine; P. I. Murray

• Publisher: Springer Netherlands
• Year: 1990
• Tongue: English
• Weight: 227 KB
• Volume: 14
• Category: Article
• ISSN: 0165-5701
• DOI: 10.1007/bf00154208

✦ Synopsis

A new technique measuring serum antoantibodies to lens proteins, employing antigen linked to magnetisable cellulose particles and fluorescent end-point detection, was used to examine patients with senile cataract and inflammatory eye disease. 40% of patients with senile cataract had antibodies to lens proteins, as did 28% of patients with heterochromic cyclitis and 20% of patients with uveitis, while there were no positive sera from patients with scleritis. The single patient with lens-induced uveitis had a high titre, but so did some patients with senile cataract. With the incorporation of a standard curve this technique offers a reliable quantitative assay for lens autoantibodies. It may provide a valuable tool for the investigation of pathogenetic mechanisms in cataract and inflammatory eye disease.