Chiral separations by capillary electrophoresis using cyclodextrin-containing gels
β Scribed by Ingrid D. Cruzado; Gyula Vigh
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 364 KB
- Volume
- 608
- Category
- Article
- ISSN
- 1873-3778
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## Abstract Chiral separation of tocainide, an antiarrythmic agent, was solved using the capillary electrophoresis method. Fifteen types of cyclodextrins were tried as chiral selective buffer additives, and baseline separation was achieved with five of them. The variables that were studied comprise
## Chiral separations by cyclodextrin-modified capillary electrophoresis -Determination of the enantiomeric excess The chiral nature of living systems has strong implications for biologically active compounds interacting with them. Consequently, the stereoisomers of drugs can differ in both pharma