Phenolic pseudo-24-crown-8 (S,S)-3, pseudo-27-crown-9 (S,S)-4, and podands (R,R)-5 and (R,R)-6 possessing phenyl groups as chiral barriers were prepared and their chiral recognition properties toward secondary neutral amines were examined. Pseudo-24-crown-8 (S,S)-3 and podand (R,R)-5 showed sufficie
Chiral recognition of secondary amines by using chiral crown ether and podand
β Scribed by Keiji Hirose; Akihito Fujiwara; Kazuhisa Matsunaga; Nobuaki Aoki; Yoshito Tobe
- Book ID
- 104252238
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 99 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Chiral crown ether (S,S)-3 having a pseudo-24-crown-8 ring and chiral podand (R,R)-4 were prepared and both exhibited good chiral recognition ability toward secondary amines, N-a-dimethylbenzylamine (15) and propranolol ( 16).
π SIMILAR VOLUMES
A direct, isocratic high-performance liquid chromatographic method is described for the enantiomeric resolution of a number of phenylalkylamines, namely, racemic cathinone, amphetamine, norephedrine, and norphenylephrhe, without sample derivatization. The separations were achieved on an S-18-crownd-