Chiral N-Phosphonyl Imine Chemistry: Asymmetric Synthesis of α-Alkyl β-Amino Ketones by Reacting Phosphonyl Imines with Ketone-Derived Enolates
✍ Scribed by Teng Ai; Jianlin Han; Zhong-Xiu Chen; Guigen Li
- Book ID
- 111368650
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 118 KB
- Volume
- 73
- Category
- Article
- ISSN
- 1747-0277
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Chiral N-phosphonyl imines attached by 1-naphthyl group were found to react with lithium malonate enolates smoothly to give chiral b-aminomalonates. Good yields and excellent diastereoselectivity were achieved for sixteen examples. The chiral auxiliary can be readily removed by treating with trifluo