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Chiral Iminoesters Derived from d -Glyceraldehyde in [3 + 2] Cycloaddition Reactions. Asymmetric Synthesis of a Key Intermediate in the Synthesis of Neuramidinase Inhibitors

✍ Scribed by Gálvez, José A.; Díaz-de-Villegas, María D.; Alías, Miriam; Badorrey, Ramón


Book ID
121348561
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
403 KB
Volume
78
Category
Article
ISSN
0022-3263

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✍ Pil-Jong Shim; Hee-Doo Kim 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 244 KB

Optically active bicyclo[4.2.0]octan-7-ones were synthesized by stereoselective intramolecular [2+2] cycloaddition of alkene-keteniminium salt derived from L-glutamic acid, based on 1,3-asymmelric induction. Synthetic application toward (+)-gibberellic acid key intermediate was also described.