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Chiral Dihydroxylation of Acronycine: Absolute Configuration of Natural cis -1,2-Dihydroxy-1,2-dihydroacronycine and Cytotoxicity of (1 R ,2 R )- and (1 S ,2 S )-1,2-Diacetoxy-1,2-dihydroacronycine

✍ Scribed by Costes, Nadine; Michel, Sylvie; Tillequin, François; Koch, Michel; Pierré, Alain; Atassi, Ghanem

Book ID
125898367
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
44 KB
Volume
62
Category
Article
ISSN
0163-3864

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Synthesis and Cytotoxic Activity of 1-Alkoxy-and 1-Amino-2hydroxy-1,2-dihydroacronycine Derivatives. -In order to get more information about the structure-activity relationships, a novel series of acronycine derivatives such as (I) and (II) (16 examples) are synthesized. The most active substance (