Chiral Brønsted Acid Catalyzed Pinacol Rearrangement

✍ Scribed by Tao Liang; Zhenjie Zhang; Prof. Dr. Jon C. Antilla

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 270 KB
• Volume: 122
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.201004778

✦ Synopsis

directly by flash column chromatography on silica gel (hexanes/ EtOAc = 10:1 to 5:1) to afford product 2 a (30.6 mg, 94 % yield, 96 % ee). Enantiomeric excess was determined by HPLC analysis using a chiral column.