Chiral Base Mediated Transformation of Cyclic 1,3-Diketones.
โ Scribed by Benjamin Butler; Thomas Schultz; Nigel S. Simpkins
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 25 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Some years ago I-3 we described a new reaction, the condensation of the vinylcyclenole ( 1) and ( 2) with the cyclic 1,3-diketones (3) and ( 4) widely used by us and by others in the total synthesis of estrone, D-homo-estrone and their analogs2-g . However the scope and limits of application of the
Diketones have been always perceived as a practical source of stabilized carbanions owing to the enhanced acidity of the active methylene hydrogen atoms.['] The alkylation of 1,3-diketones can be carried out with almost complete regio-and stereocontrol of the products.121 Every attempt at attacking