Chiral Base-Mediated Asymmetric Synthesis of Tricarbonyl(.eta.6-arene)chromium Complexes
β Scribed by Price, David A.; Simpkins, Nigel S.; MacLeod, Angus M.; Watt, Alan P.
- Book ID
- 126135506
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 274 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Axially chiral N,N-diethyl 2,6-disubstituted benzamides were stereo-selectively prepared utilizing planar chiral (arene)chromium complexes as an enantiomerically active form by following two methods. Ortho-lithiation of the enantiomerically pure planar chiral tricarbonyl(N,N-diethyl 2-methylbenzamid
The reaction of (-)lg or (+)-IS-tricarbonyl(2-substituted benzaldehyde)chromium complexes with tertbutylmethanesulfonamide dianion afforded, after decomplexation and intramolecular cyclization, the enantiomerically pure N-tert-butyl-3-(2-phenyl substituted)-1,2-thiazetidine 1,1 dioxide derivatives.
Arenechromium complexed diastereomeric aminophosphine-phosphinite ligands derived from tetrahydroisoquinoline have been synthesised and examined as chiral auxiliaries in the hydrogenation of functionalised ketones. A cyclopentyl-substituted anti-stereoisomer is providing the highest enantioselectivi