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Chiral auxiliaries for asymmetric synthesis: enantioselective addition of dialkylzincs to aldehydes catalyzed by chiral 1,2-disubstituted ferrocenyl amino alcohols

โœ Scribed by Watanabe, Makoto; Araki, Shuki; Butsugan, Yasuo; Uemura, Masaru


Book ID
120350493
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
860 KB
Volume
56
Category
Article
ISSN
0022-3263

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Chiral ligands for asymmetric synthesis:
โœ Hongying Yun; Yangjie Wu; Yusheng Wu; Kuiling Ding; Ying Zhou ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 63 KB

A series of chiral ligands 2a-d were conveniently prepared from b-amino alcohols through a two-step sequence and applied to catalysis of enantioselective addition of diethylzinc to benzaldehyde. Among them ligand 2c was found to show the best asymmetric induction for the reaction and catalyze the ad