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Chiral Anionic Surfactants for Asymmetric Mukaiyama Aldol-Type Reaction in Water.

✍ Scribed by Hui Jing Li; Hong Yu Tian; Yong Jun Chen; Dong Wang; Chao Jun Li


Publisher
John Wiley and Sons
Year
2003
Weight
105 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


πŸ“œ SIMILAR VOLUMES


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Aromatic (2c and 2d) and aliphatic (2a and 2b) anionic surfactants were employed in Sc(OTf) 3 -catalyzed aldol reactions of some labile silyl enol ethers (3a and 3b) with aromatic aldehydes in water. The results indicated that the aromatic surfactants have a better ability to inhibit the hydrolysis

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Asymmetric aldol reactions in aqueous media have been realized by using zinc-based chiral Lewis acids. The aldol products have been obtained with high yield, diastereocontrol and a good level of enantioselectivity. The reactivity of both acetophenone and propiophenone enol ether surrogates was teste

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## Abstract The combination of Ga(OTf)~3~ with chiral semi‐crown ligands (**1a**–**e**) generates highly effective chiral gallium Lewis acid catalysts for aqueous asymmetric aldol reactions of aromatic silyl enol ethers with aldehydes. A ligand‐acceleration effect was observed. Water is essential f