Aromatic (2c and 2d) and aliphatic (2a and 2b) anionic surfactants were employed in Sc(OTf) 3 -catalyzed aldol reactions of some labile silyl enol ethers (3a and 3b) with aromatic aldehydes in water. The results indicated that the aromatic surfactants have a better ability to inhibit the hydrolysis
Chiral Anionic Surfactants for Asymmetric Mukaiyama Aldol-Type Reaction in Water.
β Scribed by Hui Jing Li; Hong Yu Tian; Yong Jun Chen; Dong Wang; Chao Jun Li
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 105 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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Asymmetric aldol reactions in aqueous media have been realized by using zinc-based chiral Lewis acids. The aldol products have been obtained with high yield, diastereocontrol and a good level of enantioselectivity. The reactivity of both acetophenone and propiophenone enol ether surrogates was teste
## Abstract The combination of Ga(OTf)~3~ with chiral semiβcrown ligands (**1a**β**e**) generates highly effective chiral gallium Lewis acid catalysts for aqueous asymmetric aldol reactions of aromatic silyl enol ethers with aldehydes. A ligandβacceleration effect was observed. Water is essential f