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Chiral 1,4-dihydropyridines. Synthesis and absolute configuration.

✍ Scribed by A.I. Meyers; Nicholas R. Natale; David G. Wettlaufer; Shahin Rafii; Jon Clardy

Book ID
104243553
Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
221 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

Addition of organometallics to chiral 3-pyridyl oxazolines gave high diastereoselectivity at the 4-position of the pyridine nucleus.

Absolute configuration was determined by x-ray analysis.

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Synthesis of chiral isoquinuclidines and
Synthesis of chiral isoquinuclidines and determination of their absolute configuration
✍ M. Mehmandoust; C. Marazano; R. Singh; B. Gillet; M. CΓ©sario; J.-L. Fourrey; B.C πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 282 KB

A route to 1,2\_dihydropyridines &-substituted with chiral auxiliaries has been developed starting from commercially available chiral amines. Cycloaddition between these dihydropyridines and methyl acrylate gave, in moderate d.e., isoquinuclidines of good enantiomeric purity whose absolute configura