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Chiral 1,4-benzodiazepin-2-ones: Relationship between stereochemistry and pharmacological activity

✍ Scribed by Piero Salvadori; Carlo Bertucci; Enrico Domenici; Gino Giannaccini

Book ID
103911231
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
624 KB
Volume
7
Category
Article
ISSN
0731-7085

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✦ Synopsis

Pure enantiomers of 3-substituted-1,4-benzodiazepin-2-ones, obtained by HPLC resolution on chiral stationary phases, show significant differences in their pharmacological activity. The occurrence of biotransformation during the pharmacological test is monitored using a new chromatographic method. The reliability of the pharmacological activity data is discussed.

πŸ“œ SIMILAR VOLUMES

Nuclear magnetic resonance of 1,4-benzod
Nuclear magnetic resonance of 1,4-benzodiazepines. II Stereochemistry of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones by lanthanide shift reagents
✍ G. Romeo; M. C. Aversa; P. Giannetto; M. G. Vigorita; P. Ficarra πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 465 KB

## Abstract The sterochemistry of some 1,3‐dihydro‐2__H__‐1,4‐benxodiazepin‐2‐ones, employed as psychotherapeutic agents, is deduced by proton magnetic resonance using the paramagnetic shift reagent Eu(fod)~3~. the lanthanide induced shifts are computer simulated on the basis of the geometric param