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Chimie Des Radioprotecteurs : Révision De La Synthèse Des Acides S-[ (Aminopropyl-3) Aminoéthyl-2] Et S- [ (N-Méthylaminopropyl-3) Aminoéthyl-2] Phosphorothioiques

✍ Scribed by Joelle Laduranty; Claude Lion; DaniÈLe Mesnard; LÉOne Miginiac

Book ID
102773072
Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
540 KB
Volume
93
Category
Article
ISSN
0037-9646

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✦ Synopsis

Simple, reproducible and detailed preparations of S-I2-(3-aminoprypyl)aminoethyll and S-12-(3-N-methylaminopropyl)aminoethyll phosphorothioic acids (HO)~P(O)-S-(CHZ)~-NH-(CHZ) 3-NH-R (R = H and CH ) , named WR 2721 and WR 1680 respectively, are described. The yields of eaci step have been optimized to facilitate the synthesis of these compounds of large interest in the cancer radio-and chemotherapy.

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