Chimeric L1/E2 and L1/E6 virus-like particles for the development of a therapeutic papillomavirus vaccine
β Scribed by Daurer, Werner; Kirnbauer, Reinhard
- Book ID
- 119561854
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 188 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0923-1811
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Expression of human papillomavirus type 16 (HPV 16) fusion proteins LI deltaCE7(1-55) and LI deltaCE7(1-60) (carboxy-terminal deletion of LI replaced by 55 or 60 amino-terminal amino acids of E7) leads to formation of chimeric papillomavirus-like particles (CVLPs). After "infection" of cells by CVLP
## Abstract Persistent infection with human papillomaviruses (HPV) is a prerequisite for the development of cervical cancer. Vaccination with virusβlike particles (VLP) has demonstrated efficacy in prophylaxis but lacks therapeutic potential. HPV16 L1E7 chimeric virusβlike particles (CVLP) consist