Childhood acute lymphoblastic Leukemia: Differences in drug resistance between sub-groups of ALL
β Scribed by A. J. P. Veerman
- Publisher
- Carden Jennings Publishing
- Year
- 2002
- Tongue
- English
- Weight
- 423 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0925-5710
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## Abstract Nowadays about twoβthirds of children with acute lymphoblastic leukemia (ALL) can be cured with chemotherapy, but oneβthird die from the disease. The clinical response of leukemic cells to chemotherapy is roughly due to two factors: the effective drug levels reaching the cells and the r
## Abstract We prospectively treated 127 children with ALL with a riskβadapted regimen. All patients received the identical inductionβconsolidation therapy. The early maintenance included intermediate dose methotrexate in patients with standard risk (n = 79) and medium risk (n = 39). In addition pa