Chemotherapy of herpetic keratitis induced by acyclovir-resistant strains of herpes simplex virus type 1
โ Scribed by William J. O'Brien; Jerry L. Taylor
- Book ID
- 115678902
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 666 KB
- Volume
- 73
- Category
- Article
- ISSN
- 1555-7162
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## Abstract Herpes simplex virus type 1 (HSVโ1) is the etiological agent of herpetic keratitis. The epithelial form (โepithelial keratitisโ) is attributed mainly to destruction of the epithelium through active viral replication within the epithelium. The stromal form (โstromal keratitisโ) is associ
Drug-resistance of herpes simplex virus (HSV) is caused most frequently by mutation of the viral thymidine kinase (TK) gene. To elucidate the significance of detecting nucleotide changes of the TK gene for screening drug-resistant viruses, the frequency and variation of the genetic polymorphisms in