A patient with a sacrococcygeal malignant germ cell tumor developed epidural spinal cord compression syndrome 32 days after surgical resection of tumor. Rapid resolution of symptoms was observed after chemotherapy with vinblastine, bleomycin, and cisplatinum. There was no radiation therapy or lamine
Chemotherapeutic management of epidural neuroblastoma
β Scribed by Hayes, F. A. ;Green, A. A. ;O'Connor, D. M.
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 509 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0098-1532
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β¦ Synopsis
Nine children with neuroblastoma and spinal cord compression were managed initially with chemotherapy induction without laminectomy or radiotherapy. Of the nine children seven are neurologically normal, one has minimal residual deficits, and one remains paraplegic. The excellent results in these children, plus nine patients previously reported, emphasizes the validity of this approach in children with epidural extension of neuroblastoma.
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Although survival of children with abdominal neuroblastoma seems at this time to bc unrelated to the therapeutic effort, a method of management according to the stage of disease has been developed. Seventy-three percent of patients have metastases at the time of diagnosis. Survival is best in childr
Thirteen children with localized (Evans stage I or II) thoracic primary neuroblastoma were divided into two groups according to the type of therapy administered, in order to compare the therapeutic efficacy and morbidity of excisional surgery followed by either irradiation alone or irradiation plus
## Abstract Four patients suffering spinal cord compression resulting from epidural metastases were treated with adrenocorticosteroid hormones. For 2 patients, prompt relief of symptoms followed glucocorticoid therapy alone and was associated with marked shrinkage or disappearance of the metastasis