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Chemotactic Peptide Analogues Centrally Constrained Chemotactic N-Formyltripeptides: Synthesis, Conformation, and Activity of Two New Analogues
β Scribed by Giampiero Pagani Zecchini; Mario Paglialunga Paradisi; Ines Torrini; Gino Lucente; Gaia Mastropietro; Maurizio Paci; Susanna Spisani
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 745 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0365-6233
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π SIMILAR VOLUMES
The synthesis and the biological activity towards human neutrophils of some N-formyl-Met-Leu-Phe-OMe analogues containing (9-phenylalaninol (Pheol) or its derivatives in place of the native phenylalanine are reported. While the analogue containing Pheol (4) was found to be devoid of significant biol
The new C a -tetrasubstituted a-amino acid residue 2- [2-(methylthio)ethyl]methionine (Dmt) has been introduced into the reference chemotactic tripeptide HCO-Met-Leu-Phe-OMe ( f MLP-OMe) in place of the leucine or methionine, respectively. The biological activity of the new analogues [Dmt 2 ] f MLP-