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Chemotactic Peptide Analogues. Synthesis and Chemotactic Activity of N-Formyl-Met-Leu-Phe Analogues Containing (S)-Phenylalaninol Derivatives

✍ Scribed by Giampiero Pagani Zecchini; Mario Paglialunga Paradisi; Ines Torrini; Susanna Spisani

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 402 KB
Volume: 328
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19953280908

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✦ Synopsis

The synthesis and the biological activity towards human neutrophils of some N-formyl-Met-Leu-Phe-OMe analogues containing (9-phenylalaninol (Pheol) or its derivatives in place of the native phenylalanine are reported. While the analogue containing Pheol (4) was found to be devoid of significant biological activity, its esters 3 and 5, although inactive as chemoattractants, are able to strongly stimulate superoxide production and are active with a lower efficacy in the lysozyme release.

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