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Chemosensitivity in vitro to 2-chlorodeoxyadenosine and 9-β-d-arabinofuranosyl-2-fluoroadenine in previously unexposed cases of chronic lymphocytic leukemia

✍ Scribed by Tomi Koski; Leena Vilpo; Juhani Vilpo

Book ID: 114119567
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 57 KB
Volume: 23
Category: Article
ISSN: 0145-2126
DOI: 10.1016/s0145-2126(98)00169-6

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## BACKGROUND. T-cell lymphoid blastic phase (BP) transformation is rare in chronic myelogenous leukemia (CML). 2-amino-9-␤-D-arabinosyl-6-methoxy-9H-guanine (GW506U78), a prodrug of arabinosylguanine (ara-G), is effective in T-cell leukemias. ## METHODS. The authors present a case of a 48-year